Caffeine citrate
Acetaminophen / Aspirin / Caffeine, Acetaminophen / Butalbital / Caffeine, Acetaminophen / Butalbital / Caffeine / Codeine, Aspirin / Butalbital / Caffeine, Aspirin / Butalbital / Caffeine / Codeine, Cafcit, Caffeine, Caffeine /, Darvon, Dhc, Excedrin (migraine Relief), Fioricet, Gencebok, Lanorinal, Migergot, Nymusa, Orphengesic, Peyona, Synalgos-dc, Synalgos-dc-a, Trezix (caffeine citrate) is a small molecule pharmaceutical. Caffeine citrate was first approved as Darvon w/ asa on 1982-01-01. It is used to treat apnea and fatigue in the USA. It has been approved in Europe to treat apnea.
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Brand Name | Status | Last Update |
|---|---|---|
| cafcit | New Drug Application | 2024-04-08 |
| caffeine citrate | ANDA | 2025-07-28 |
| caffeine citrate oral solution | ANDA | 2023-07-31 |
| excedrin pm triple action caplets and excedrin extra strength pain reliever | C200263 | 2024-03-14 |
| excedrin pm triple action caplets and excedrin tension headache | C200263 | 2024-03-14 |
| fioricet | ANDA | 2021-01-01 |
| fioricet with codeine | ANDA | 2021-03-01 |
| norgesic | ANDA | 2024-01-08 |
| norgesic forte | ANDA | 2024-01-27 |
| orphenadrine citrate aspirin caffeine | ANDA | 2024-07-25 |
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64 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Apnea | D001049 | — | R06.81 | 1 | 1 | 5 | 5 | 8 | 20 |
| Premature birth | D047928 | EFO_0003917 | O60 | 1 | 1 | 6 | 3 | 7 | 17 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | 1 | — | — | 1 | 1 | 3 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | 1 | — | — | 1 | 1 | 3 |
| Bronchopulmonary dysplasia | D001997 | — | P27.8 | — | 1 | 1 | 1 | 1 | 3 |
| Respiratory insufficiency | D012131 | — | J96.9 | — | — | — | 1 | 2 | 3 |
| Anesthesia | D000758 | — | — | — | — | — | 2 | — | 2 |
| Syndrome | D013577 | — | — | — | 1 | — | 1 | — | 2 |
| Intubation | D007440 | — | — | — | — | — | 1 | — | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypoxia | D000860 | — | R09.02 | 3 | — | 2 | — | — | 5 |
| Brain diseases | D001927 | — | G93.40 | 3 | — | 1 | — | — | 4 |
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | 3 | — | 1 | — | — | 4 |
| Brain hypoxia-ischemia | D020925 | EFO_1000846 | P91.6 | 3 | — | 1 | — | — | 4 |
| Ischemia | D007511 | EFO_0000556 | — | 2 | — | 1 | — | — | 3 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 1 | — | — | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | 1 | — | — | 1 |
| Respiratory tract diseases | D012140 | — | — | — | 1 | 1 | — | — | 1 |
| Respiration disorders | D012120 | — | J00-J99 | — | 1 | 1 | — | — | 1 |
| Leiomyoma | D007889 | — | D25 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ileus | D045823 | — | K56.7 | — | 1 | — | — | — | 1 |
| Narcolepsy | D009290 | EFO_0000614 | G47.4 | 1 | 1 | — | — | — | 1 |
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | 1 | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | — | 1 |
| Neurobehavioral manifestations | D019954 | EFO_0004364 | — | 1 | 1 | — | — | — | 1 |
| Alcoholic intoxication | D000435 | — | — | 1 | 1 | — | — | — | 1 |
| Laparoscopic cholecystectomy | D017081 | — | — | — | 1 | — | — | — | 1 |
| Depression | D003863 | — | F33.9 | — | 1 | — | — | — | 1 |
| Postoperative cognitive complications | D000079690 | — | — | — | 1 | — | — | — | 1 |
| Delirium | D003693 | — | R41.0 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | 1 | 2 |
| Postoperative pain | D010149 | — | G89.18 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Acute kidney injury | D058186 | — | N17 | 1 | — | — | — | — | 1 |
| Hypothermia | D007035 | — | T68 | 1 | — | — | — | — | 1 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 1 | — | — | — | — | 1 |
| Eczema | D004485 | — | L30.9 | 1 | — | — | — | — | 1 |
| Dermatitis | D003872 | — | L30.9 | 1 | — | — | — | — | 1 |
| Necrotizing enterocolitis | D020345 | EFO_0003928 | K55.3 | 1 | — | — | — | — | 1 |
| Enterocolitis | D004760 | EFO_1001481 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wheelchairs | D014910 | — | — | — | — | — | — | 1 | 1 |
| Dietary supplements | D019587 | — | — | — | — | — | — | 1 | 1 |
| Bronchiolitis | D001988 | — | — | — | — | — | — | 1 | 1 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 1 | 1 |
| Nutritional physiological phenomena | D009747 | — | — | — | — | — | — | 1 | 1 |
| Newborn infant diseases | D007232 | — | — | — | — | — | — | 1 | 1 |
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Anorexia | D000855 | — | R63.0 | — | — | — | — | 1 | 1 |
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | — | — | — | — | 1 | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Caffeine citrate |
| INN | — |
| Description | Caffeine citrate, sold under the brand name Cafcit among others, is a medication used to treat a lack of breathing in premature babies. Specifically it is given to babies who are born at less than 35 weeks or weigh less than 2 kilograms (4.4Â lb) once other causes are ruled out. It is given by mouth or slow injection into a vein.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1c(=O)c2c(ncn2C)n(C)c1=O.O=C(O)CC(O)(CC(=O)O)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 2097117-68-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200569 |
| ChEBI ID | — |
| PubChem CID | 6241 |
| DrugBank | — |
| UNII ID | — |
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Migergot – Horizon Therapeutics Public
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Black-box Warning
Black-box warning for: Fioricet, Fioricet with codeine, Trezix
Adverse Events
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28,661 adverse events reported
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