Caffeine citrate
Acetaminophen / Aspirin / Caffeine, Acetaminophen / Butalbital / Caffeine, Acetaminophen / Butalbital / Caffeine / Codeine, Aspirin / Butalbital / Caffeine, Aspirin / Butalbital / Caffeine / Codeine, Cafcit, Caffeine, Caffeine /, Darvon, Dhc, Excedrin (migraine Relief), Fioricet, Gencebok, Lanorinal, Migergot, Nymusa, Orphengesic, Peyona, Synalgos-dc, Synalgos-dc-a, Trezix (caffeine citrate) is a small molecule pharmaceutical. Caffeine citrate was first approved as Darvon w/ asa on 1982-01-01. It is used to treat apnea and fatigue in the USA. It has been approved in Europe to treat apnea.
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Brand Name | Status | Last Update |
|---|---|---|
| 357 super magnum | OTC monograph final | 2016-05-19 |
| 999 cold remedy | OTC monograph not final | 2013-09-17 |
| 999 ganmaoling | OTC monograph final | 2012-07-03 |
| acetaminophen 250mg aspirin 250mg caffeine 65mg | C200263 | 2024-12-26 |
| acetaminophen 500mg caffeine 60mg pyrilamine maleate 15mg | C200263 | 2024-12-25 |
| acetaminophen 500mg caffeine 65mg | OTC monograph not final | 2020-11-16 |
| acetaminophen aspirin and caffeine | ANDA | 2024-03-05 |
| acetaminophen aspirin caffeine | ANDA | 2024-11-18 |
| acetaminophen, aspirin and caffeine | ANDA | 2024-12-10 |
| acetaminophen, aspirin, caffeine | C200263 | 2024-05-08 |
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994 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 42 | 2 | — | 6 | 48 | 98 |
| Apnea | D001049 | HP_0002104 | R06.81 | 1 | 4 | 6 | 5 | 12 | 27 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 5 | 4 | 3 | 1 | 17 | 27 |
| Premature birth | D047928 | EFO_0003917 | O60 | 1 | 3 | 7 | 3 | 13 | 25 |
| Headache | D006261 | HP_0002315 | R51 | 2 | 1 | 7 | 4 | 9 | 22 |
| Neoplasms | D009369 | — | C80 | 5 | 1 | — | 1 | 8 | 15 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 2 | 8 | 2 | 4 | 15 |
| Syndrome | D013577 | — | — | — | — | 1 | 1 | 12 | 14 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | 1 | — | 2 | 11 | 14 |
| Affect | D000339 | — | — | — | — | — | 1 | 12 | 13 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | 1 | 1 | 1 | — | 9 | 12 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 1 | — | 10 | 11 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 1 | 2 | — | 4 | 10 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | 4 | 2 | 1 | — | 3 | 9 |
| Weight loss | D015431 | HP_0001824 | — | — | 2 | 2 | — | 7 | 9 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | 2 | — | 7 | 9 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 2 | 1 | — | 4 | 7 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 2 | — | 5 | 7 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 1 | — | 5 | 6 |
| Sclerosis | D012598 | — | — | 1 | 1 | 1 | — | 3 | 6 |
Show 55 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 2 | 3 | — | — | 19 | 23 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | 1 | — | — | 12 | 14 |
| Depression | D003863 | — | F33.9 | — | 2 | — | — | 10 | 12 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 3 | — | — | 8 | 11 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 2 | — | — | 7 | 10 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | — | — | 7 | 8 |
| Overweight | D050177 | — | E66.3 | 2 | 1 | — | — | 5 | 7 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | 1 | — | — | 5 | 6 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 4 | 1 | — | — | 1 | 6 |
| Dermatitis | D003872 | HP_0011123 | L30.9 | 4 | 1 | — | — | 1 | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug interactions | D004347 | — | — | 11 | — | — | — | 3 | 14 |
| Dietary supplements | D019587 | — | — | 1 | — | — | — | 6 | 7 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | 5 | 6 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 2 | — | — | — | 3 | 5 |
| Psoriasis | D011565 | EFO_0000676 | L40 | 5 | — | — | — | — | 5 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | 4 | 5 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | 3 | — | — | — | 2 | 5 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | 1 | — | — | — | 4 | 5 |
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | 2 | 4 |
| Chronic pain | D059350 | HP_0012532 | — | 1 | — | — | — | 3 | 4 |
Show 52 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fatigue | D005221 | HP_0012378 | R53.83 | — | — | — | — | 21 | 21 |
| Sleep | D012890 | GO_0030431 | — | — | — | — | — | 13 | 13 |
| Sleep deprivation | D012892 | — | F51.12 | — | — | — | — | 12 | 12 |
| Sleep wake disorders | D012893 | — | G47 | — | — | — | — | 12 | 12 |
| Placebos | D010919 | — | — | — | — | — | — | 11 | 11 |
| Urinary incontinence | D014549 | HP_0000020 | R32 | — | — | — | — | 11 | 11 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 10 | 10 |
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | — | — | — | — | 9 | 9 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | — | — | 9 | 9 |
| Seizures | D012640 | HP_0002069 | G40.4 | — | — | — | — | 9 | 9 |
Show 346 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Caffeine citrate |
| INN | — |
| Description | Caffeine citrate, sold under the brand name Cafcit among others, is a medication used to treat a lack of breathing in premature babies. Specifically it is given to babies who are born at less than 35 weeks or weigh less than 2 kilograms (4.4 lb) once other causes are ruled out. It is given by mouth or slow injection into a vein.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1c(=O)c2c(ncn2C)n(C)c1=O.O=C(O)CC(O)(CC(=O)O)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 2097117-68-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200569 |
| ChEBI ID | — |
| PubChem CID | 6241 |
| DrugBank | — |
| UNII ID | — |
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Migergot – Horizon Therapeutics Public
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Safety
Black-box Warning
Black-box warning for: Acetaminophen, caffeine, dihydrocodeine bitartrate, Acetaminophen,caffeine and pyrilamine maleate, Ascomp with codeine, Butalbita,acetaminophen and caffeine, Butalbital, acetaminophen, and caffeine, Butalbital, acetaminophen, caffeine, Butalbital, acetaminophen, caffeine and codeine phosphate, Butalbital, acetaminophen, caffeine, and codeine phosphate, Butalbital, aspirin, caffeine and codeine phosphate, Darvon-n, Ergotamine, Ergotamine tartrate and caffeine, Fioricet, Fioricet with codeine, Migergot, Trezix
Adverse Events
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26,686 adverse events reported
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