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Drug ReportsCaffeine citrate
Caffeine citrate
Acetaminophen / Aspirin / Caffeine, Acetaminophen / Butalbital / Caffeine, Acetaminophen / Butalbital / Caffeine / Codeine, Aspirin / Butalbital / Caffeine, Aspirin / Butalbital / Caffeine / Codeine, Cafcit, Caffeine, Caffeine /, Darvon, Dhc, Excedrin (migraine Relief), Fioricet, Gencebok, Lanorinal, Migergot, Nymusa, Orphengesic, Peyona, Synalgos-dc, Synalgos-dc-a, Trezix (caffeine citrate) is a small molecule pharmaceutical. Caffeine citrate was first approved as Darvon w/ asa on 1982-01-01. It is used to treat apnea and fatigue in the USA. It has been approved in Europe to treat apnea.
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Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name
Status
Last Update
cafcitNew Drug Application2024-04-08
caffeine citrateANDA2025-07-28
caffeine citrate oral solutionANDA2023-07-31
excedrin pm triple action caplets and excedrin extra strength pain relieverC2002632024-03-14
excedrin pm triple action caplets and excedrin tension headacheC2002632024-03-14
fioricetANDA2021-01-01
fioricet with codeineANDA2021-03-01
norgesicANDA2024-01-08
norgesic forteANDA2024-01-27
orphenadrine citrate aspirin caffeineANDA2024-07-25
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Indications
FDA
EMA
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Clinical
Clinical Trials
65 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G43——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCaffeine citrate
INN—
Description
Caffeine citrate, sold under the brand name Cafcit among others, is a medication used to treat a lack of breathing in premature babies. Specifically it is given to babies who are born at less than 35 weeks or weigh less than 2 kilograms (4.4 lb) once other causes are ruled out. It is given by mouth or slow injection into a vein.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
Cn1c(=O)c2c(ncn2C)n(C)c1=O.O=C(O)CC(O)(CC(=O)O)C(=O)O
Identifiers
PDB—
CAS-ID2097117-68-3
RxCUI—
ChEMBL IDCHEMBL1200569
ChEBI ID—
PubChem CID6241
DrugBank—
UNII ID—
Target
No data
Variants
No data
Financial
Revenue by drug
$
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â‚£
Migergot – Horizon Therapeutics Public
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Estimated US medical usage
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Safety
Black-box Warning
Black-box warning for: Fioricet, Fioricet with codeine, Trezix
Adverse Events
Top Adverse Reactions
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1,641 adverse events reported
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